Why is the sickle cell allele a nuisance trait rather than an advantage in most of the modern world?

Answers

Answer 1

Answer:

Sickle cell anaemia is a generic disorder which affects the red blood cells. The red blood cells assumes a sickle shape and contains lesser amount of the protein hemoglobin. Hemoglobin helps in the necessary transport of oxygen to other parts of the body.

The sickle cell allele is known to be advantageous to mainly people who stay in developing/underdeveloped counties who malaria endemic . People with the sickle cell allele have a higher chance of survival against malaria than people without this allele.

In modern countries malaria isn’t prevalent there due to the lack of vectors, poverty and environmental conditions which tends to support the survival of the mosquito. This means the sickle cell allele isn’t advantageous in this region.


Related Questions

Outline one cost and one benefit of living in a group.

Answers

Answer:

Cost: competition for mates, competition for resources

Benefit: better protection from predators (ex. a fish in a school of fish has greater chances of not getting eaten because of the large number of other fish)

A box of jello has a mass of 250 g. How many boxes must be bought to have 1 Kg of jello? *

2
3
4
6​

Answers

Answer:

4

Explanation:

According to the question, one box of jello has a mass of 250grams.

The question wants us to find how many boxes of jello would collectively weigh 1kg.

Since the units of weight here are in grams (g) and kilograms (kg), we need to convert to the same unit

1kilogram (kg) is equal to 100 grams (g).

Hence, if 1 box of jello weighs 250g

1000g of jello box will be 1000/250 in number

1000 ÷ 250 = 4.

Hence, 4 boxes of jello will weigh 1000g or 1kg.

The blank is the pathway of the cell

Answers

Answer: Endoplasmic Reticulum

Explanation: The Endoplasmic reticulum is called the 'Highway or the Pathway of the cell'. It transports the waste, the enzymes and  all the other substances inside or outside the cell. There are 2 types of Endoplasmic reticulum; Smooth and rough ER. There functions are as follows:-

Smooth ER - It has lipids in the form of fats and no ribosomes

Rough ER - It has ribosomes i.e. proteins . It detoxifies the toxins.

Final answer:

In biology, 'pathway' often refers to structures such as plasmodesmata in plant cells or a series of biochemical reactions. Plasmodesmata provide a channel for intercellular communication, facilitating the symplastic pathway for substance movement. Pathways also represent the process of cellular development and signal transmission within organisms.

Explanation:

The 'pathway' mentioned in the question can refer to various processes or structures within a cell that enable substances to move from one part to another or enable a series of biological reactions. In the context provided, the term 'pathway' seems to be specifically referring to 'plasmodesmata', which are channels between the cell walls of adjacent plant cells that allow for the passage of materials from one cell's cytoplasm to another. Additionally, a pathway can refer to a biological pathway, which is a series of biochemical reactions that produce a specific product or bring about a change in a cell, like the transmission of signals or regulation of gene expression.

Plasmodesmata are essential for the 'symplastic pathway', one of the two means of intercellular communication in plant cells, the other being the apoplastic pathway. The symplastic pathway involves the movement of water and solutes across the cytoplasm of plant cells through plasmodesmata, while the apoplastic pathway involves movement through the cell walls and spaces between cells.

The description also touches on cellular development, such as the developmental pathway that illustrates how the 556 cells of C. elegans larvae originate from a single zygote, highlighting cell division and programmed cell death (apoptosis).

List five words or terms you associate with mental health by typing one word or phrase at a time and pressing enter.

Answers

Answer:

nervous breakdown.

Depression

Madness

Insanity

Attitude

Explanation:

Mental health refers to a state of well-being. This state depends on different factors which include physical health, intellectual health, self-care, gratitude aptitude, sociability, and biological factors.

Mental health is a well-being state. This state is fundamental at all stages of life, from childhood adolescence to adulthood.

Mental health include:

Physical health. People with physical difficulties may be at risk of developing poor mental health.

Intellectual health. In a similar manner to physical health, people with intellectual problems (e.g., behavior disorders) may also be at risk of developing chronic mental difficulties.

Self-care. Mental self-care includes all activities that help to stay mentally healthy.

Sociability. Social isolation is a trigger for mental illness.

Gratitude aptitude. It is imperative to make an effort to say 'thank you' to other persons, this aptitude enhances mental health.

Biological factors. It is well known that different biological factors such as gene expression and the presence of neurotransmitters in the brain at low/high levels, can affect mental health.

In conclusion, mental health depends on different factors such as physical health, intellectual health, self-care, gratitude aptitude, sociability, and biological factors.

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Which Punnet square would have 50% of the offspring be heterozygous and 50% of the offspring be homozygous recessive?

A)
B)
C)
D)

Answers

Answer:

Punnet square C

Explanation:

It would be DD, DD, dD, and dD, amking it a 50% chance

Which of the following are not eukaryotes? Fungi, plants, animals, bacteria

Answers

Answer:

D) bacteria

Explanation:

Cell structure is the main characteristic distinguishing bacterial cells from eukaryotic ones. Earth is home to both prokaryotic and eukaryotic cell types. Eukaryotic cells have a nucleus that houses their genetic material, while prokaryotic cells do not possess a nucleus and have free-floating genetic material.

The main distinction between the two cell types is this: Many single-celled organisms, known as prokaryotes, call bacteria and archaea home. Prokaryotic cells are the oldest, smallest, and most fundamental components of all forms of life. From plants and animals to fungi and protists, every living thing in the eukaryotic domain has complex eukaryotic cells that are physically similar to every other eukaryotic species.

W X
Urine is carried from the kidneys
to the urinary bladder.
Urine is temporarily stored before
it is released.
Y Z
Waste products are filtered
through nephrons.
Urine is carried from the urinary
bladder and released outside the body.

The functions of different parts of the urinary system are given in the boxes.

A) W → Y → Z → X
B) W → X → Y → Z
C) Y → Z → W → X
D) Y → W → X → Z

Answers

The correct sequence of the functions in the urinary system is b) W → X → Y → Z. This involves urine being transported from the kidneys to the bladder, stored, and then excreted. The nephron filters waste products from the blood to form urine.

The student asked about the sequence of functions in the urinary system. The correct order is W → X → Y → Z: Urine is carried from the kidneys to the urinary bladder (W) → Urine is temporarily stored before it is released (X) → Waste products are filtered through nephrons (Y) → Urine is carried from the urinary bladder and released outside the body (Z).

This aligns with the functions of the urinary system where the nephron filters blood to form urine, which is then transported by the ureters to the urinary bladder for storage and finally excreted via the urethra.

Consider the following statements:
1. Mutations always have a negative effect on an individual.
2. Mutations can have a positive effect on the individual.
3. Mutations can have no effect on an individual.
4. Mutations can have a negative effect on an individual.
Which of the statements above is/are TRUE?
1 and 3 only
2.3 and 4 only
1,2,3 and 4
1 only

Answers

Answer:

2.3 and 4 only

Explanation:

Mutation is an alteration in the gene of an organism, which can cause some physiological and physical changes in the organism.

Mutation can have a favorable positive effect on an individual (e.g increasing microorganisms resistance to antibiotics) increasing its chances of adaptability and survivability, it can have a negative effect on the individual (e.g cancerous cells) which can reduce its survivability, and can have no effect at all on the individual (e.g having eyes with 2 different colors).

Assume that for a given gene a mutation creates an allele that functions as a dominant negative. The gene codes for a protein that forms a tetramer (4) within the cell. If at least one of the subunits has the mutant structure the entire protein is inactivated. For a heterozygous individual, what percent of the tretramers present in the cell will be inactive?

Answers

Answer: 100%

Explanation:

if the mutation presents autosomal dominant inheritance, each affected individual will show 100% alteration in the protein, thus , being dominant, it is considered that the disease pattern will predominate even if it has genes that do not express it since these will be recessive and canceled by the dominant ones.

which oraginsm can be classified in domain Bacteria
A. a predatory organism that depends on hunting plant eaters for food
B. a multicellular organism that reproduces via spores and gets its food from a dead log
C. a photosynthetic organism that undergoes sexual reproduction and produces seeds in cones
D. a unicellular organism that has a simple structure and is commonly found in human intestines

Answers

Final answer:

The correct classification for an organism in the domain Bacteria is a unicellular, prokaryotic organism commonly found in human intestines.

Explanation:

The organism that can be classified in the domain Bacteria is D. a unicellular organism that has a simple structure and is commonly found in human intestines. Such organisms are prokaryotic, meaning they lack a defined cell nucleus, and domain Bacteria encompasses these types of unicellular life forms. Members of this domain are quite diverse and can be found in nearly every habitat, which includes being beneficial or benign residents within the human body. To further illustrate, d. bacteria living in the gut of humans fall under this domain because they are unicellular, prokaryotic, and can have positive interactions with their hosts.

The Black Albatross and the smaller Grey Albatross are closely related species that nest on sandstone cliffs in Antarctica and the sub-Antarctic islands. Like the Black Albatross, the Grey Albatross builds nests on the cliffs. Building nests on the cliffs helps to protect the young from generalist predators such as the Brown Skua and feral cats. However, unlike Black Albatross, Grey Albatross need to spend the winter wandering the ocean further to the north where the temperatures are warmer. Black Albatross are able to survive the colder southern winters because of their larger body size and greater insulation. From these observations, we can conclude that: a) The Black Albatross is more at risk of extinction due to competition for biotic resources with humans.b) The distributions of the two albatross species are limited by some shared and some different biotic factors.c) The distributions of both albatross species are limited by the same biotic factors but their distributions are limited by different abiotic factors.d) The distributions of both albatross species are limited by the same abiotic factors but their distributions are limited by different biotic factors.e) The Black Albatross and the Grey Albatross are actually two populations of the same species.

Answers

Answer:

The correct answer is c) The distributions of both albatross species are limited by the same biotic factors but their distributions are limited by different abiotic factors

Explanation:

Both of the species are limited in their nesting sites by predators, which represent the limiting biotic factors. They need to nest on the cliffs to avoid predators' access to their calves and in that way, they can ensure reproductive success.

Temperature is the limiting abiotic factor. Grey Albatross need to spend the winter in areas where the temperatures are warmer, while the Black Albatross are able to survive the colder southern winters.

: Hair color is a human trait controlled by 7 genes with a Heritability of 1. Based on this, provide a 1-2 sentence explanation of the correct classification for what type of trait hair color is and how the information provided supports that classification (single-gene trait, polygenic trait, multifactorial polygenic trait, environmentally controlled trait).

Answers

Answer:

Polygenic trait

Explanation:

A polygenic trait is a type of trait whose phenotype observed is affected by more than one genes i.e expression of the trait is controlled by not only a single gene but many. These traits include height or skin color and they display that display a continuous distribution; the hair color is controlled by 7 genes as described which is more than more.

Final answer:

Hair color is a polygenic trait influenced by multiple genes, reflected in the heritability score of 1, which implies genetic factors account for the observed variation in hair color among individuals.

Explanation:

Human hair color is classified as a polygenic trait because it is influenced by multiple genes. The heritability of 1 indicates that genetic factors entirely determine the variation observed in hair color among individuals within a population. This classification is supported by the fact that hair color results from the interaction of several genes, each contributing to the production and distribution of melanin, the pigment responsible for hair color. Examples include genes like MC1R, which affects the type of melanin produced, contributing to the range of hair colors from black, brown, blond, to red. Other genes such as TYR and TYRP1 also play significant roles in melanin production and, consequently, in determining hair color.

Which of the following is an advantage of conservation?
A. Animals are overhunted.
B. Extinct organisms come back to life.
C. Limited resources are used wisely.
w
D. More resources are used.

Answers

An advantage of conservation is B.
B because it’s just the way it is

In the lab, metabolic poisons can be used to study ATP synthesis and oxygen consumption. Many of these poisons have – or have had – other uses, from diet aids to animal poisons to antibiotics.

Poison Action
oligomycin binds to F0 and blocks the proton channel
carbon monoxide inhibits cytochrome oxidase by reacting with heme a3
trifluorocarbonylcyanide-
phenylhydrazone (FCCP) increases membrane proton permeability
antimycin prevents electron flow between cytochrome b and
cytochrome c
bongkrekic acid binds to inward‑facing site of ATP‑ADP translocase

Classify the metabolic poisons as electron transport inhibitors, uncoupling agents, ATP synthase inhibitors, or transport inhibitors.

Answers

Answer:

Carbon monoxide and antimycin are classified as electron transport inhibitors, FCCP as uncoupling agent, oligomycin as ATP synthase inhibitors, and bongkrekic acid as transport inhibitor.

Explanation:

The electron transport inhibitors refers to the substances, which get combine with distinct constituents of the ETC and prevent the function of the carrier. These substances binds with the carrier and prevent its transformation, which eventually results in halting of the process. The most commonly known electron transport inhibitors are rotenone, carbon monoxide, antimycin, etc.

A molecule that prevents oxidative phosphorylation in mitochondria and prokaryotes, or photo-phosphorylation in cyanobacteria and chloroplasts by inhibiting the production of ATP is known as ATP synthase inhibitors. The most commonly known ATP synthase inhibitor is oligomycin.

Similarly to oligomycin, FCCP or trifluorocarbonylcyanide phenylhydrazone is a potent uncoupler or uncoupling agent that prevents the synthesis of ATP by enhancing membrane proton permeability.

Bongkrekic acid refers to a highly toxic transport inhibitor that prevents the ADP/ATP translocase by combining with the inward facing site of ATP-ADP translocase.

Final answer:

Metabolic poisons can be classified based on their actions. Oligomycin and carbon monoxide are ATP synthase inhibitors and electron transport inhibitors respectively. Trifluorocarbonylcyanide-phenylhydrazone (FCCP) is an uncoupling agent. Antimycin is an electron transport inhibitor and bongkrekic acid is a transport inhibitor.

Explanation:

Metabolic poisons can be classified into different categories based on their actions:

Oligomycin: ATP synthase inhibitor, as it binds to F0 and blocks the proton channelCarbon monoxide: Electron transport inhibitor, as it inhibits cytochrome oxidase by reacting with heme a3Trifluorocarbonylcyanide-phenylhydrazone (FCCP): Uncoupling agent, as it increases membrane proton permeabilityAntimycin: Electron transport inhibitor, as it prevents electron flow between cytochrome b and cytochrome cBongkrekic acid: Transport inhibitor, as it binds to the inward-facing site of ATP-ADP translocase

Guys please I need help. Please show your answers like this

1)
2)
3)

The best answer will get 100 points transferred to their account

Answers

Answer:

I think number 10 across is bush because bush meat is raw meat prepared from animals

9 across is headache or vomiting

7 across fruit bats

4 across fever

A group of scientists is studying a protist species.

The species is currently classified in the phylum Chrysophyta because of its physical characteristics. However, after the scientists analyze the species' DNA, they discover that the DNA is most similar to protists in the phylum Phaeophyta.

What will the scientists most likely do next?

Answers

Answer:

Do further testing on the species to discover whether  or not the species is related.

Explanation:

Answer:

They will reclassify the species in the phylum Phaeophyta.

Explanation:

according to study island

When using a pie cut, which of the following would be true of the blemish?
It would be only a crack.
It would be only in the bark of the tree.
It would be near the surface of one side.
It would have come from termite damage.

Answers

Answer:

it would be near the surface of one side

Chapter 23 Cancer GeneticsCOMPREHENSION QUESTIONS True/False1. Most cancers arise from defects in DNA. 2. The presence of a single mutated gene is sufficient for retinoblastoma cancer to develop. 3. miRNAs play a critical role in initiating tumor development. 4. A single gene mutation may predispose a person to developing cancer. 5. Overactive telomerase enzyme deletes the ends of chromosomes and can cause cancer. 6. Relatively few people inherit all of the genetic changes that cause cancer. 7. Proto-oncogenes do not cause cancer. 8. Most tumors arise from germ-line mutations that accumulate during our life span. 9. Xeroderma pigmentosum includes predisposition to cancer due to defects in a specific DNA repair system.

Answers

Answer:

Explanation:

1. Most cancers arise from defects in DNA. True defects in the DNA including mutations can lead to cancer.

2. The presence of a single mutated gene is sufficient for retinoblastoma cancer to develop. False: the presence one mutant copy of the gene of RB1 is not sufficient enough to cause cancer

3. miRNAs play a critical role in initiating tumor development. True: MiRNAs may function as either oncogenes or tumor suppressors under certain conditions. They have been shown as biomarkers for human cancer diagnosis.

4. A single gene mutation may predispose a person to developing cancer. False: many mutations in the cells coupled with other risk factors may predispose a person to developing cancer

5. Overactive telomerase enzyme deletes the ends of chromosomes and can cause cancer. False: Instead the enzyme just keeps adding more and more repeats to the telomereres and the cancer cell can keep dividing without losing DNA and genes at the ends of the chromosomes

6. Relatively few people inherit all of the genetic changes that cause cancer: True: there are some genetic changes that are not inherited but acquired.

7. Proto-oncogenes do not cause cancer. True: they do not cause cancer but a mutation in them might lead to the activation of oncogenes that causes cancer.

8. Most tumors arise from germ-line mutations that accumulate during our life span. False: most common cancers are as a result of somatic or acquired mutation that have accumulated during our life span. Germline mutations are hereditary

9. Xeroderma pigmentosum includes predisposition to cancer due to defects in a specific DNA repair system.

True: a defect in the DNA repair system paritcularly in enzymes invloved in this repair

Which of the following is the definition for specifiction

Answers

Answer:

an act of describing or identifying something precisely or of stating a precise requirement.

Explanation:

if you see something close to that then your good

good day and be safe

∵∴∵∴∵∴∵∴∵      

⊕ΘΞΠΤ⊕      

∵∴∵∴∵∴∵∴∵

Answer:

kinda like describing or identifying something

Explanation:

g four pairs of species are given, with descriptions of how they interact. Match each system of differential equations with a species pair, and indicate which species is and which is . (a) represents the population. represents the population. (b) represents the population. represents the population. (c) represents the population. represents the population. (d) represents the population. represents the population.

Answers

Answer:

c

Explanation:

describe how the host is damaged by the parasite​

Answers

Answer:

A parasite is an organism that lives within or on a host. The host is another organism. The parasite uses the host's resources to fuel its life cycle. It uses the host's resources to maintain itself.

Explanation:

2. Is Ellie correct in thinking that TSH is a thyroid hormone? Why is her TSH level low instead of high?

Answers

Answer: Ellie is incorrect in thinking TSH is a thyroid hormone. TSH is a pituitary hormone. TSH is the hormone that tells the thyroid to either create more or less of T3 and T4. Ellie’s TSH islow because the hypothalamus is telling the pituitary gland to release lower levels of TSH because the thyroid is pumping out to high of levels of T3 and T4.

Explanation:

Final answer:

Ellie is incorrect because TSH is produced by the anterior pituitary gland, not the thyroid. A low TSH level can lead to a reduced metabolic rate, causing symptoms like weight gain and fatigue. TSH levels are controlled by a negative feedback system involving thyroid hormones T3 and T4.

Explanation:

Ellie is mistaken in thinking that TSH (thyroid-stimulating hormone) is a thyroid hormone. TSH is actually produced by the anterior pituitary gland and plays a crucial role in regulating the secretion of thyroid hormones (T3 and T4) by the thyroid gland. The thyroid hormones are the ones that are produced by the thyroid gland, not TSH itself.

When there is a deficiency in TSH, it suggests that there is insufficient stimulation for the thyroid gland to produce the thyroid hormones necessary for maintaining a normal metabolic rate. A low metabolic rate can lead to symptoms such as weight gain and fatigue, which are commonly observed in hypothyroidism.

The levels of TSH are regulated through a negative feedback system.

If there's an overproduction of thyroid hormones (as seen in hyperthyroidism), the high levels of T3 and T4 will suppress the release of TRH (thyrotropin-releasing hormone) from the hypothalamus and TSH from the anterior pituitary gland to reduce thyroid hormone production, hence maintaining homeostasis.

Fungi, like plants, respond to stimuli from the environment. Some of their responses to environmental stimuli are the same and some are different.

How do fungi respond to environmental stimuli? Choose ALL of the statements that apply.

Fungi, like plants, respond to light.
Both fungi and plants respond to touch.
Fungi, do not respond to light because they are not autotrophs.
Fungi hyphae grow toward water.
Both plants and fungi grow against gravity

Answers

Final answer:

Fungi respond to light, touch, water presence, and gravity, showcasing their adaptability to environmental conditions. Although they do not perform photosynthesis, their responses to environmental stimuli ensure survival and growth in diverse habitats.

Explanation:

How fungi respond to environmental stimuli is a fascinating aspect of their biology, showing both similarities and differences with plants. Here are the accurate statements about fungi's response to environmental stimuli:

Fungi, like plants, respond to light.Both fungi and plants respond to touch.Fungi hyphae grow toward water.Both plants and fungi grow against gravity.

Contrary to a common misconception, fungi do respond to light, even though they are not autotrophs. This phototropic response does not stem from a need to photosynthesize but may influence the direction of growth or the development of fruiting bodies. Similarly, fungi exhibit hydrotropism, where their hyphae grow towards sources of water, and they can respond to touch and gravity, demonstrating a complex interaction with their environment. Unlike plants, fungi do not carry out photosynthesis because they lack chlorophyll; they obtain nutrients through heterotrophic means, absorbing organic compounds from their surroundings.

Which conclusion is true based on the information in this passage?
Changing one organism in a food web would not have any effect on any other food web.
o
It is easy to see all the ways that food webs are connected.
Food chains are always separate from each other.
Food webs are connected to each other and sensitive to any changes,

Answers

Answer:

True

True

False

True

Explanation:

Answer:

Food webs are connected to each other and sensitive to any changes.

Explanation:

An example of a type of bacteria which is an autotroph is ________

Answers

Answer:

Algae

Explanation:

Explain how yeast makes dough rise

Answers

Answer:

The yeast metabolizes these simple sugars and exudes a liquid that releases carbon dioxide and ethyl alcohol into existing air bubbles in the dough. As the sugars are metabolized, carbon dioxide and alcohol are released into the bread dough, making it rise.

i'm a baker :) i hope this helps

Explanation:

Yeast helps dough rise through alcoholic fermentation, wherein it metabolizes carbohydrates to produce carbon dioxide.

Yeast is a crucial ingredient in bread making that helps dough to rise. Specifically, Saccharomyces cerevisiae, a type of yeast, metabolizes the carbohydrates in flour.

This metabolic process, known as alcoholic fermentation, yields two products: ethanol and carbon dioxide (CO₂). The carbon dioxide gas gets trapped in the dough, forming bubbles that expand during the rising process.

As a result, the dough rises and exhibits a spongy structure due to these gas bubbles.

Jasmine is conducting an investigation and moves a magnet near a compass, causing the compass needle to move. However, the magnet never touched the compass. This observation is evidence for which characteristics of magnetic fields?

Answers

Answer:

This observation shows the ability of the magnetic fields to create lines that can align the position of the magnets.

Explanation:

Compasses have a small magnet on the pointer and this explains why the compass pointer aligns with a magnet, even if the magnet does not touch the compass.

That's because the magnet on the compass pointer creates a magnetic field around it. This magnetic field is capable of creating lines that have the ability to align the position of different magnets, even if they do not touch.

Answer:

They have a north pole and a south pole.

Explanation:

g Assume that for a given gene a mutation creates an allele that functions as a dominant negative. The gene codes for a protein that forms a tetramer (4) within the cell. If at least one of the subunits has the mutant structure the entire protein is inactivated. For a heterozygous individual, what percent of the tretramers present in the cell will be inactive?

Answers

Answer:

At least 50% of the tetramers will be inactive for this individual

Explanation:

A protein resulting from a mutation that is dominant negative will have an detrimental impact on the wild-type protein as well. Especially if the mutated protein can interact with the same substances as the normal, wild-type protein.

For an individual who is heterozygous, there will be one wild-type copy and one mutant copy of the allele present. For each copy, a protein will be expressed and the tetramers from the mutant copy will be defective - so 50% of the protein tetramers will be inactive at least.

Hope that answers the question, have a great day!

Which of these is an effect of nonpoint-source pollution on agricultural land?

Answers

Answer:

Answer choices ?..

Direct evidence can include all of the following except:

A toxicology report

A signed ransom note

A surveillance film

A sample of hair w/o the follicle

Answers

A sample of hair without the follicle

Direct evidence can include all of the following except a sample of hair without the follicle. Thus, the correct option for this question is D.

What is Direct evidence?

Direct evidence may be defined as a type of evidence that significantly deals with the testimony that attests to the truth and reality of the fact to be proved. In a more simple sense, it may be characterized as evidence that proves a fact directly without any inference or presumption.

If a sample of hair does not have a hair follicle, it does not deliver an example of direct evidence. This is because a hair follicle reveals the exact fact and understanding behind the individual.

And the rest of the options like a toxicology report, a signed ransom note, and a surveillance film all illustrate the examples of direct evidence. If the evidence is significantly real and true, then the fact is conclusively established.

Therefore, a sample of hair without the follicle is a declaration that does not include direct evidence.

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